A new experiment on stem cell research shows great promise for the technology on stem cell as a cure for erectile dysfunction on older men. According to a study being conducted by several researchers from the American Urological Association, headed by Dr. Tom Lue, it is possible for a autologous adipose derived stem cells (ADSCs) to be used to regenerate erectile function.In adipose tissue there are stem cells as demonstrated by immunohistochemistry, RT-PCR and Western blotting experiments. The adipose derived stem cells (ADSCs) reside near small blood vessels. CD34 staining identifies 60% of peri-vascular areas as harboring ADSCs. It occurs in new blood vessels, and is a sign of regeneration. ADSCs can be harvested by liposuction or fat excision. Adipose cells are digested and ADSCs are cultured for further induction, labeling or gene transfection. ADSCs can also be used for in vivo tissue engineering. In vitro induction can result in
hepatocytes, beta cells to produce insulin or endothelial cells. In vivo, ADSCs placed in muscle can differentiate into skeletal muscle, placed near blood vessels become smooth muscle and in fat can become fat cells. The differentiate into component cell types and integrate into the tissue. Four weeks after injection of ADSCs following cavernous nerve crush injury in a rat model, there is return of function.A study showed injection of umbilical cord blood stem cells into men having failed PDE5 inhibitors resulted in improved erectile function. This is only a pilot experiment, but shows great promise.
These results were presented by Dr. Lue at the Annual Meeting of the American Urological Association held at Orlando, Florida las May 2008.
